According to the American Heart Association, 12% of patients never fill their prescriptions,
12% fill them but do not take them, and 29% start taking them but stop prematurely. Only
47% take them all (1).
Compliance by subjects in clinical trials can be much higher, but there are reports of average compliance rates in some trials of only 43% to 78% (2,3)
References
1. “Statistics you need to know”, American Heart Association, last accessed 7/18/2005 at
http://www.americanheart.org/presenter.jhtml?identifier=107.
2. “Adherence to Medication”, Lars Osterberg and Terence Blaschke, New England Journal
of Medicine, August 4, 2005
3. “Medication Compliance as a Feature in Drug Development”, H. Kastrissios and T.F.
Blaschke, Annual Review Pharmacology & Toxicology, 1997
4. “Addressing Expanded Clinical Trials”, David Vaczek, Pharmaceutical & Medical
Packaging News, April 2007
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